Immunological Aspects of Infectious Diseases by R. J. Elin (auth.), George Dick (eds.)

By R. J. Elin (auth.), George Dick (eds.)

In the 1st position might I say how thankful I and others are to people who have contributed chapters for this ebook; them all are renowned for his or her learn at the topic on which they've got written and every has indicated the historical past to his personal expert box by means of delivering an intensive bibliography giving this publication a complete reference checklist of over 2,500. even if there were huge, immense advances in immunology over fresh years, a lot of the recent wisdom on the subject of infectious illnesses used to be scattered over the world's literature and is now introduced jointly in one quantity. in addition, whereas a few formerly unknown infectious ailments have lately been came across (e.g. Marburg and Lassa virus infections and Legionnaires' sickness) to which many new concepts were utilized, there looked to be no transparent assertion of the explanation for his or her use, or for his or her extra exploitation in the various extra universal infectious illnesses that are mentioned during this book.

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Sample text

Huppert and Keeney49 noted a four-fold reduction in experimental ringworm of the foot by prior local immunization with an extract of the infecting agent. There is a real possibility that the therapeutic value of immunoprophylaxis has been underrated. Intractable ringworm is by no means unknown in this griseofulvin era, and a reappraisal of the benefits to be gained by controlled manipulation of the immune responses of the host may be profitable. Subjects infected with ringworm may have id reactions.

The parasitic phase of Histoplasma is yeastlike, not mycelial, and it might have been anticipated that immunologically active yeast-cell components would provide a suitable source of antigens for both skin and serological tests. In view of the amount of research into all aspects of histoplasmosis which has been initiated over the past three decades it is perhaps surprising that so little attention has been paid to the extraction, characterization and application of purified skin-test antigens. The failure of investigators to focus on this area is all the more surprising in view of the known cross-reactivity of histoplasmin with extracts of other pathogenic and non-pathogenic fungi.

Positive skin responses were obtained in only five of the 143 control subjects tested with sporotrichin, in contrast to the 116 reacting to C. albicans and four reacting to Coccidioides. Blastogenic responses of peripheral blood lymphocytes correlated well with the skin-test results. One patient with articular sporotrichosis had positive skin and lymphocyte transformation tests. Since marked crossreactivity was noted in this study between results with S. schenckii and C. albicans, the authors suggest that the co-existence of intact cellular immune responses and exposure to C.

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